Human Respiratory Epithelial Tissue Models for Opioid-Reversal Nasal Spray Perme

This contract will provide specialized human-derived nasal and respiratory epithelial tissue models and associated culture media required for the FDA-funded project "In Vitro Characterization to Support Development and Approval of Generic Drug Products for Opioid Overdose Reversal" under opioids research awards. The tissues will be used to test permeation of naloxone and nalmefene nasal spray products across physiologically relevant epithelial barriers, generating biorelevant in vitro data to evaluate formulation-dependent drug absorption and support development of alternative in vitro approaches for non-Q1/Q2 generic opioid-overdose reversal products. The purchase is specifically anticipated in the awarded proposal, which allocates project funds for batch orders of 3D human-derived respiratory epithelial tissue models needed for the permeation studies.

Estimated value

> $25K and < $250K

Est. solicitation date

Nov 1, 2026

Anticipated award

Jan 1, 2027