Civic AI
Civic AI
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SAM.govDARPA-SN-26-67
Open

Research Opportunity: DNA-Protein Epigenetic Chemistry Engineering (D-PECHE)

Response deadline
Jun 24, 2026
Closed
Date posted
May 18, 2026

Description

UPDATE: The purpose of Amendment 1 to DARPA-SN-26-67, the DNA-Protein Epigenetic Chemistry Engineering (D-PECHE) Special Notice (SN), is to clarify submission instructions and deadlines. The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals to demonstrate proof-of-concept for novel mechanisms for writing and erasing epigenetic base modifications in DNA. Mechanisms capable of modifying the epigenome offer new opportunities to control DNA-protein interactions and to study the functions and applications of rare or novel epigenetic modifications. This research opportunity will result in demonstrations of novel technologies to modify nucleic acids in vitro.

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